Neuropathic pain stems from injured or damaged nerves and can happen anywhere on your body. Patients have described the pain as a burning sensation, a zapping, or like pins and needles.
Topical clonidine (0.1%) has shown to provide moderate relief for neuropathic pain but also for hypertension and chronic pain. Clinical trials are ongoing, and the results have shown promise as an effective alternative to oral doses with adverse effects.
Patients, particularly those with peripheral neuropathy (or nerve pain extending to your limbs), have also enjoyed moderate relief with topical gabapentin (6%) and ketamine (10%).